(rac)-Nebivolol-d4 MedChemExpress (MCE)

Product Name	(rac)-Nebivolol-d4
Synonyms	(rac)-Nebivolol-d4;2,2-dideuterio-2-[[1,1-dideuterio-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
CAS	1219407-55-2
EINECS
Chemical Formula	C22H21D4F2NO4
Molecular Weight	409.459653512
inchi
Package	1 mg
Price	Email to quote
Descriptions	(rac)-Nebivolol-d4 (rac)-Nebivolol-d4 MedChemExpress (MCE) HY-B0203BS1 1219407-55-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions (rac)-Nebivolol-d4 (rac)-Nebivolol-d4 MedChemExpress (MCE) HY-B0203BS1 1219407-55-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. (rac)-Nebivolol-d4 is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. β adrenergic receptor \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1 49(2):430-9. [Content Brief] [3]. Mercanoglu G, et al. The effects of nebivolol on apoptosis in a rat infarct model. Circ J. 2008 Apr 72(4):660-70. [Content Brief]
Supplier Website	https://www.medchemexpress.com/rac-nebivolol-d4.html
Last Update	2025-05-21 16:50:25

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