Kinetensin MedChemExpress (MCE)

Product Name	Kinetensin
Synonyms	Kinetensin
CAS	103131-69-7
EINECS
Chemical Formula	C56H85N17O11
Molecular Weight	1172.4
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Kinetensin Kinetensin MedChemExpress (MCE) HY-P1255 103131-69-7 Kinetensin (human) 99.89% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions Kinetensin Kinetensin MedChemExpress (MCE) HY-P1255 103131-69-7 Kinetensin (human) 99.89% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) Room temperature in continental US may vary elsewhere. Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma. The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2]. Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2]. Rats[2] Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2]. Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2]. Human Endogenous Metabolite Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu \| \| \| \| \| \| \| \| \| \| [1]. Mogard MH, et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14 136(3):983-8. [Content Brief] [2]. Sydbom A, et al. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr 27(1-2):68-71. [Content Brief]
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Last Update	2025-05-21 16:50:25

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