Hinokitiol MedChemExpress (MCE)

Product Name	beta-thujaplicin
Synonyms	Hinokitiol HINOKITIOL B-THUJAPLICIN BETA-THUJAPLICIN beta-thujaplicin BETA-THUJAPLICINE Beta-Thujaplicine Synonyms Hinokitiol HINOKITIOL B-THUJAPLICIN BETA-THUJAPLICIN beta-thujaplicin BETA-THUJAPLICINE Beta-Thujaplicine 2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIENE 2-HYDROXY-4-ISOPROPYLCYCLOHEPTA-2,4,6-TRIEN-1-ONE 2-HYDROXY-4-ISOPROPYL-2,4,6-CYCLOHEPTATRIEN-1-ONE 2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one 2-hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
CAS	499-44-5
EINECS	207-880-7
Chemical Formula	C10H12O2
Molecular Weight	164.2
inchi	InChI=1/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Hinokitiol Hinokitiol MedChemExpress (MCE) HY-B2230 499-44-5 β-Thujaplicin 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US Descriptions Hinokitiol Hinokitiol MedChemExpress (MCE) HY-B2230 499-44-5 β-Thujaplicin 99.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months Room temperature in continental US may vary elsewhere. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 µM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner[1]. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes[2]. U87MG and T98G glioma cells are cultured in Dulbecco's modified Eagle's medium with Ham's F12 medium (DMEM/F-12) containing 10% fetal bovine serum. Cell viability is determined using MTT to evaluate the cytotoxicity of hinokitiol. Cells are seeded in 24-well plates (1×105 cells/well) in the presence of various concentration of hinokitiol or vehicle at 37°C for 24 h followed by incubation with MTT reagent. The blue formazan crystals of viable cells are dissolved in DMSO and then evaluated spectrophotometrically at 570 nm. DMSO-treated group is set as 100%, and data are presented as percentage of DMSO control. IC50 values are calculated by the GraFit software. DNMT1 Nrf2 \| \| \| \| \| \| \| \| \| \| [1]. Ouyang WC, et al. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemother Pharmacol. 2017 Aug 80(2):411-419. [Content Brief] [2]. Seo JS, et al. Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biol. 2017 Feb 27 18(1):14. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Hinokitiol.html
Last Update	2025-05-21 16:50:25

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