BetulinaldehydeBetulinaldehyde
MedChemExpress (MCE)
HY-N0084
13159-28-9
Betulinic aldehyde
Betunal
98.72%
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Room temperature in continental US
may vary elsewhere.
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca2+/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.
Betulinaldehyde (20, 40, 80 μM
24 h) inhibits the colony formation ability of A549 cells in a concentration-dependent manner[3].Betulinaldehyde (20 μM
24 h) inhibits the phosphorylation of Akt, MAPK and STAT3 in A549 cells[3].Betulinaldehyde (80 μM, 160 μM
24 h) leads vascular remodeling in rats with carotid balloon injurys, and inhibits intracellular Ca2+ levels[4].
Betulinaldehyde (50-200 mg/kg
ip
once daily for 1 week) inhibits the growth of A549 tumor xenografs in nude mice in vivo[3].
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[1]. Chung PY, et al. Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde. Res Microbiol. 2013 May
164(4):319-26. [Content Brief]
[2]. Chung PY, et al. Transcriptional profiles of the response of methicillin-resistant Staphylococcus aureus to pentacyclic triterpenoids. PLoS One. 2013
8(2):e56687. [Content Brief]
[3]. Huang PH, et al. Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy. Sci Rep. 2023 Jan 13
13(1):743. [Content Brief]
[4]. Fu Y, et al. Betulinaldehyde inhibits vascular remodeling by regulating the microenvironment through the PLCγ1/Ca2+/MMP9 pathway. Phytomedicine. 2023 Jul 25
116:154891. [Content Brief]