Embelin MedChemExpress (MCE)

Product Name	embelin from embelia seeds
Synonyms	Embelin EMBELIN emberine embelicacid APOPTOSIS ACTIVATOR III embelin from embelia seeds 2,5-dihydroxy-3-undecyl-p-benzoquinon Synonyms Embelin EMBELIN emberine embelicacid APOPTOSIS ACTIVATOR III embelin from embelia seeds 2,5-dihydroxy-3-undecyl-p-benzoquinon 2,5-Dihydroxy-3-undecyl-p-benzoquinone 4-dione,2,5-dihydroxy-3-undecyl-5-cyclohexadiene-1 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione 2,5-Cyclohexadiene-1,4-dione,2,5-dihydroxy-3-undecyl-
CAS	550-24-3
EINECS	208-979-8
Chemical Formula	C17H26O4
Molecular Weight	294.39
inchi	InChI=1/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Embelin Embelin MedChemExpress (MCE) HY-17473 550-24-3 Embelic acid Descriptions Embelin Embelin MedChemExpress (MCE) HY-17473 550-24-3 Embelic acid Emberine NSC 91874 98.75% 4°C, protect from light In solvent : -80°C, 2 years -20°C, 1 year (protect from light) Room temperature in continental US may vary elsewhere. Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Embelin (Embelic acid) has a minimal effect on normal prostate epithelial and fibroblast cells with low levels of XIAP[1]. XIAP 4.1 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004 47(10):2430-2440. [Content Brief]* [2]. Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007 71(1):209-219. [Content Brief] [3]. Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017 32(11):2371-2378. [Content Brief]
Supplier Website	https://www.medchemexpress.com/embelin.html
Last Update	2025-05-21 16:50:25

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