SKI-606 hydrate MedChemExpress (MCE)

Product Name	Bosutinib monohydrate
Synonyms	bosutinib hydrate;Bosutinib Monohydrate;Bosutinib monohydrate
CAS	918639-08-4
EINECS
Chemical Formula	C26H31Cl2N5O4
Molecular Weight	548.46144
inchi
Package	5 mg;10 mg
Price	Email to quote
Descriptions	Bosutinib hydrate Bosutinib hydrate MedChemExpress (MCE) HY-10158A 918639-08-4 SKI-606 hydrate 99.97% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Bosutinib hydrate Bosutinib hydrate MedChemExpress (MCE) HY-10158A 918639-08-4 SKI-606 hydrate 99.97% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively. Bosutinib hydrate is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range[2]. Bosutinib (oral gavage 75 mg/kg twice daily or 150 mg/kg once daily) hydrate has activity against human KU812 xenografts in nude mice. Bosutinib (150 mg/kg once daily, 5 days weekly) hydrate has activity against syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts[2]. IC50: 314 nmol/L (Csk, Src family protein tyrosine kinases) IC50: 2.4 nmol/L(Abl kinase). In Vitro Bosutinib hydrate is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Bosutinib hydrate Related Antibodies Cell Proliferation Assay[2] Cell Line: The leukemic Bcr-Abl+ cell lines (KCL22, K562, KU812, and Lama84) \| \| \| \| \| \| \| \| \| \| [1]. Jorge E Cortes, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012 Oct 1 30(28):3486-92. [Content Brief] [2]. Miriam Puttini, et al. In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells. Cancer Res. 2006 Dec 1 66(23):11314-22. [Content Brief]
Supplier Website	https://www.medchemexpress.com/bosutinib-hydrate.html
Last Update	2025-05-21 16:50:25

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