MY33-3 MedChemExpress (MCE)

Product Name	MY33-3 (hydrochloride)
Synonyms	MY33-3 (hydrochloride)
CAS	2204280-42-0
EINECS
Chemical Formula
Molecular Weight
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	MY33-3 hydrochloride MY33-3 hydrochloride MedChemExpress (MCE) HY-123966A 2204280-42-0 99.40% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions MY33-3 hydrochloride MY33-3 hydrochloride MedChemExpress (MCE) HY-123966A 2204280-42-0 99.40% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction. MY33-3 hydrochloride (1 μM pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells[1]. MY33-3 hydrochloride (0.1-10 μM 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells[2]. MY33-3 hydrochloride (60 mg/kg p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3[1]. MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability[3]. \| \| \| \| \| \| \| \| \| \| [1]. Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15 137:86-95. [Content Brief] [2]. Fernández-Calle R, et, al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20 10(1):20259. [Content Brief] [3]. Mao S, et, al. Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. J Mol Neurosci. 2022 Jan 72(1):48-55. [Content Brief]
Supplier Website	https://www.medchemexpress.com/my33-3-hydrochloride.html
Last Update	2025-05-21 16:50:25

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