GPR52 antagonist-1 MedChemExpress (MCE)

Product Name	CAY10786
Synonyms	CAY10786;GPR52-IN-43(CAY10786)
CAS	1239987-91-7
EINECS
Chemical Formula	C15H14OS
Molecular Weight	242.34
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	GPR52 antagonist-1 GPR52 antagonist-1 MedChemExpress (MCE) HY-145468 1239987-91-7 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions GPR52 antagonist-1 GPR52 antagonist-1 MedChemExpress (MCE) HY-145468 1239987-91-7 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. GPR52 antagonist-1 (Compound 43) (5 mg/kg i.p. once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice[1]. IC50: 0.63 μM (GPR52)[1] In Vivo GPR52 antagonist-1 (Compound 43) (5 mg/kg i.p. once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. \| \| \| \| \| \| \| \| \| \| [1]. Wang C, et al. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. J Med Chem. 2021 Jan 28 64(2):941-957. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gpr52-antagonist-1.html
Last Update	2025-05-21 16:50:25

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