dCeMM3 MedChemExpress (MCE)

Product Name	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide
Synonyms	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide;2-((1H-Benzo[d]imidazol-2-yl)thio)-N-(5-chloropyridin-2-yl)acetamide
CAS	311787-85-6
EINECS
Chemical Formula	C14H11ClN4OS
Molecular Weight	318.78
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	dCeMM3 dCeMM3 MedChemExpress (MCE) HY-144976 311787-85-6 98.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions dCeMM3 dCeMM3 MedChemExpress (MCE) HY-144976 311787-85-6 98.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. dCeMM3 (Compound 3) is a molecular glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM3 (0.01–100 µM, 3 days) exhibits significant cytotoxicity in wild-type KBM7 cells, and its effect was dependent on UBE2M activity[1]. dCeMM3 (7 µM, 5 hours) significantly reduces Cyclin K levels in KBM7 cells[1]. \| \| \| \| \| \| \| \| \| \| [1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar 17(3):361]. Nat Chem Biol. 2020 16(11):1199-1207. [Content Brief]
Supplier Website	https://www.medchemexpress.com/dcemm3.html
Last Update	2025-05-21 16:50:25

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