Triptycene-1,4-quinone MedChemExpress (MCE)

Product Name	9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
Synonyms	9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
CAS	3519-82-2
EINECS
Chemical Formula	C20H12O2
Molecular Weight	284.313
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	INCA-6 INCA-6 MedChemExpress (MCE) HY-108544 3519-82-2 Triptycene-1,4-quinone 98.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions INCA-6 INCA-6 MedChemExpress (MCE) HY-108544 3519-82-2 Triptycene-1,4-quinone 98.85% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the ?calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling. INCA-6 (5 μM for 24-hour) prevents?transient outward K+?current (Ito)?downregulation in 3-Hz cells[1]. Pre-treatment of BV-2 cells with INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in BV-2 cells. INCA-6 also inhibits ATP-induced CXCL2 expression in rat primary microglia[2].? INCA-6 (5 μM) reduces SERCA2 transcript levels as well as protein expression, in the absence or in the presence of ?thapsigargin (TG)[3]. INCA-6 (1.0 and 2.5 μM 24 hours?) treatment significantly decreases both VEGF and serum-induced human retinal microvascular endothelial cells (HRMEC) proliferation, but does not affect baseline proliferation[4]. INCA-6 (5.0, or 25.0 μM) treatment significantly reduces pathologic neovascularization in oxygen-induced retinopathy (OIR)[4]. \| \| \| \| \| \| \| \| \| \| [1]. Ling Xiao, et al. Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes. Circ Res. 2008 Sep 26 103(7):733-42. [Content Brief] [2]. Miho Shiratori,et al. P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. J Neurochem. 2010 Aug 114(3):810-9. [Content Brief] [3]. Anand Mohan Prasad, et al. Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011 Jan 300(1):H173-80. [Content Brief] [4]. Colin A Bretz, et al. The role of the NFAT signaling pathway in retinal neovascularization. Invest Ophthalmol Vis Sci. 2013 Oct 25 54(10):7020-7. [Content Brief]
Supplier Website	https://www.medchemexpress.com/inca-6.html
Last Update	2025-05-21 16:50:25

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