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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameSKI-I
SynonymsSKI-I;Sphingosine Kinase Inhibitor, SKI-I
CAS306301-68-8
EINECS
Chemical FormulaC25H18N4O2
Molecular Weight406.44
inchi
Package10 mM * 1 mL;1 mg;5 mg;10 mg
PriceEmail to quote
DescriptionsSKI-I

SKI-I

MedChemExpress (MCE)

HY-115735

306301-68-8

99.14%

4°C, protect from light *In solvent : -80°C, 6 months

Descriptions

SKI-I

SKI-I

MedChemExpress (MCE)

HY-115735

306301-68-8

99.14%

4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)

Room temperature in continental US
may vary elsewhere.

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines.

SKI-I (Compound I
5 μg/mL) inhibits SK activity by 99%[1]. SKI-I (10 μM
24 h) induces the apoptosis of T24 cells[1].

IC50: 1.2 μM (ST-hSK)
11 μM (hERK2)[1] Cellular Effect Cell Line Type Value Description References

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[1]. French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15
63(18):5962-9. [Content Brief]

[2]. Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep
45(9):4149-56. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/ski-i.html
Last Update2025-05-21 16:50:25
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