C-021 MedChemExpress (MCE)

Product Name	CCR4 Antagonist
Synonyms	CCR4 Antagonist
CAS	864289-85-0
EINECS
Chemical Formula	C27H41N5O2
Molecular Weight	467.7
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	C-021 C-021 MedChemExpress (MCE) HY-103364 864289-85-0 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions C-021 C-021 MedChemExpress (MCE) HY-103364 864289-85-0 99.95% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM. The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML), thus providing intrinsic clearance values (CLint). C-021 exhibits CLint value of 17,377 mL/h/kg[1]. The potency of C-021 (Compound 1b) is evident after subcutaneous administration in the murine oxazolone-induced contact hypersensitivity test, a known model of acute skin inflammation. When C-021 is administered orally, however, very little inhibition is observed[1]. C-021 (1 mg/kg i.p. daily for 3 days) significantly less microgliosis in acute liver failuremice[2]. CCR4 \| \| \| \| \| \| \| \| \| \| [1]. Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1 17(1):64-73. [Content Brief] [2]. Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10 11:121. [Content Brief]
Supplier Website	https://www.medchemexpress.com/c-021.html
Last Update	2025-05-21 16:50:25

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