Evifacotrep MedChemExpress (MCE)

Product Name	4-chloro-5-{4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl}pyridazin-3(2H)-one
Synonyms	Evifacotrep 5-chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-1H-pyridazin-6-one 4-chloro-5-{4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl}pyridazin-3(2H)-one Synonyms Evifacotrep 5-chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-1H-pyridazin-6-one 4-chloro-5-{4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl}pyridazin-3(2H)-one 3(2H)-Pyridazinone, 4-chloro-5-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl]-
CAS	2413739-88-3
EINECS
Chemical Formula	C18H12ClF4N5O2
Molecular Weight	441.77
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Evifacotrep Evifacotrep MedChemExpress (MCE) HY-132813 2413739-88-3 99.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Evifacotrep Evifacotrep MedChemExpress (MCE) HY-132813 2413739-88-3 99.55% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5/TRPC4 with IC50s ≤50 nM. Evifacotrep (1 μM 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4)[1]. Evifacotrep (30 mg/kg sc once daily or twice daily for 10 days) results in reduced urinary albumin excretion on following injury with puromycinaminonucleoside (PAN)[1]. TRPC5[1] In Vitro Evifacotrep (1 μM 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4)[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Evifacotrep Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. WO2020061162
Supplier Website	https://www.medchemexpress.com/evifacotrep.html
Last Update	2025-04-01 14:45:47

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