GDC-0310 MedChemExpress (MCE)

Product Name	(S) -methyl 5-cyclopropyl-4- ( (1- (1- (3, 5-dichlorophenyl) ethyl) piperidin-4-yl) methoxy) -2-fluorobenzoate
Synonyms	(S) -methyl 5-cyclopropyl-4- ( (1- (1- (3, 5-dichlorophenyl) ethyl) piperidin-4-yl) methoxy) -2-fluorobenzoate
CAS	1788063-52-4
EINECS
Chemical Formula	C25H28Cl2FNO3
Molecular Weight	480.3991232
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	GDC-0310 GDC-0310 MedChemExpress (MCE) HY-139081 1788063-52-4 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions GDC-0310 GDC-0310 MedChemExpress (MCE) HY-139081 1788063-52-4 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7. GDC-0310 exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7[1]. GDC-0310 shows substantially improved Nav selectivity and ADME properties[1]. GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively[1]. hNav1.4 3.4 nM (IC50) hNav1.2 38 nM (IC50) hNav1.6 198 nM (IC50) hNav1.1 202 nM (IC50) hNav1.5 551 nM (IC50) Nav1.7 0.6 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Brian S Safina, et al. Discovery of Acyl-sulfonamide Na v 1.7 Inhibitors GDC-0276 and GDC-0310. J Med Chem. 2021 Mar 25 64(6):2953-2966. [Content Brief] [2]. Lei Xu, et al. Voltage-gated sodium channels: structures, functions, and molecular modeling. Drug Discov Today. 2019 Jul 24(7):1389-1397. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gdc-0310.html
Last Update	2025-05-21 16:50:25

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