PROTAC EED degrader-2 MedChemExpress (MCE)

Product Name	PROTAC EED degrader-2
Synonyms	PROTAC EED degrader-2
CAS	2639882-69-0
EINECS
Chemical Formula	C50H58FN11O6S
Molecular Weight	960.13
inchi
Package	1 mg
Price	Email to quote
Descriptions	PROTAC EED degrader-2 PROTAC EED degrader-2 MedChemExpress (MCE) HY-130615 2639882-69-0 99.90% 4°C, protect from light In solvent : -80°C, 6 months Descriptions PROTAC EED degrader-2 PROTAC EED degrader-2 MedChemExpress (MCE) HY-130615 2639882-69-0 99.90% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. PROTAC EED degrader-2 is a von Hippel-Lindau-based PROTAC targeting EED with a pKD of 9.27. PROTAC EED degrader-2 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.11) targeting the EED subunit. PROTAC EED degrader-2 (Compound PROTAC 1) binds to EED with a pKD of 9.27±0.05 and inhibits PRC2 function with a pIC50 of 8.11±0.09[1]. PROTAC EED degrader-2 (0.01-100 μM 14 days) can potently inhibit proliferation of an EZH2 mutant DLBCL cell line Karpas422[1]. PROTAC EED degrader-2 (0.1-3 μM 48 hours) reduces the protein levels of EED, EZH2, H3K27me3 in Karpas422 cells[1]. PROTAC EED degrader-2 (1 μM 1-24 h) promotes degradation of EED, EZH2, and SUZ12 in Karpas422 cells[1]. VHL \| \| \| \| \| \| \| \| \| \| [1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/protac-eed-degrader-2.html
Last Update	2025-05-21 16:50:25

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