IMB-301 MedChemExpress (MCE)

Product Name	IMB-301
Synonyms	IMB-301;1H-Imidazole,1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]-
CAS	64009-84-3
EINECS
Chemical Formula	C19H17Cl2FN2O
Molecular Weight	379.26
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	IMB-301 IMB-301 MedChemExpress (MCE) HY-122156 64009-84-3 99.08% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions IMB-301 IMB-301 MedChemExpress (MCE) HY-122156 64009-84-3 99.08% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM). Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. IMB-301 is able to increase virion encapsidation of hA3G via its ability to impair the degradation of hA3Gby Vif, which results in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits the replication of HIV-1 in a hA3G-dependent manner[1]. \| \| \| \| \| \| \| \| \| \| [1]. Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018 8(1):8067. Published 2018 May 23. [Content Brief]
Supplier Website	https://www.medchemexpress.com/imb-301.html
Last Update	2025-05-21 16:50:25

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