CCI-007 MedChemExpress (MCE)

Product Name	Ethyl 2-(4-((2-amino-4-oxothiazol-5(4H)-ylidene)methyl)-2-methoxyphenoxy)acetate
Synonyms	CCI 007);CCI-007 (CCI00;Ethyl 2-(4-((2-amino-4-oxothiazol-5(4H)-ylidene)methyl)-2-methoxyphenoxy)acetate
CAS	939228-52-1
EINECS
Chemical Formula	C15H16N2O5S
Molecular Weight	336.36
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	CCI-007 CCI-007 MedChemExpress (MCE) HY-122698 939228-52-1 98.45% 4°C, protect from light In solvent : -80°C, 6 months Descriptions CCI-007 CCI-007 MedChemExpress (MCE) HY-122698 939228-52-1 98.45% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells. CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia[1]. Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2[1]. Resistance to CCI-007 can occur by upregulation of MLL target gene expression[1]. \| \| \| \| \| \| \| \| \| \| [1]. Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19 7(29):46067-46087. [Content Brief] [2]. Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May 38(20):3824-3842. [Content Brief]
Supplier Website	https://www.medchemexpress.com/cci-007.html
Last Update	2025-05-21 16:50:25

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