CP-868388 MedChemExpress (MCE)

Product Name	CP-868388
Synonyms	CP-868388 (-)-CP-868388 UNII-999KY5ZIGB CP-868388 free base (S)-2-(3-(1-((4-Isopropylbenzyloxy)carbonyl)piperidin-3-yl)phenoxy)-2-methylpropanoic acid 2-methyl-2-{3-[(3S)-1-({[4-(propan-2-yl)phenyl]methoxy}carbonyl)piperidin-3-yl]phenoxy}propanoic acid Synonyms CP-868388 (-)-CP-868388 UNII-999KY5ZIGB CP-868388 free base (S)-2-(3-(1-((4-Isopropylbenzyloxy)carbonyl)piperidin-3-yl)phenoxy)-2-methylpropanoic acid 2-methyl-2-{3-[(3S)-1-({[4-(propan-2-yl)phenyl]methoxy}carbonyl)piperidin-3-yl]phenoxy}propanoic acid 1-Piperidinecarboxylic acid, 3-[3-(1-carboxy-1-methylethoxy)phenyl]-, 1-[[4-(1-methylethyl)phenyl]methyl] ester, (3S)-
CAS	702681-67-2
EINECS
Chemical Formula	C26H33NO5
Molecular Weight	439.54
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	CP-868388 free base CP-868388 free base MedChemExpress (MCE) HY-116699 702681-67-2 99.08% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions CP-868388 free base CP-868388 free base MedChemExpress (MCE) HY-116699 702681-67-2 99.08% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions. CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC50 of 4.7 nM) and PGC-1α peptide[1]. CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC50 of 18 nM in HepG2 cells[1]. CP-868388 (0-3 mg/kg oral gavage once daily for 2 days male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%[1]. hPPARα 10.8 nM (Ki) hPPARγ 3.47 μM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Christopher D Kane, et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb 75(2):296-306. [Content Brief]
Supplier Website	https://www.medchemexpress.com/cp-868388-free-base.html
Last Update	2025-05-21 16:50:25

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