(R)-Bicalutamide MedChemExpress (MCE)

Product Name	(R)-BICALUTAMIDE
Synonyms	R-Bicalutamide R-Bicalutimide R-BICALUTIMIDE (R)-BICALUTAMIDE (R)-(-)-BICALUTAMIDE N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Flurophenyl)Thio]-2-Hydroxy-2-Methyl-Propanamide (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Synonyms R-Bicalutamide R-Bicalutimide R-BICALUTIMIDE (R)-BICALUTAMIDE (R)-(-)-BICALUTAMIDE N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Flurophenyl)Thio]-2-Hydroxy-2-Methyl-Propanamide (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide (2R)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (R)- Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-
CAS	113299-40-4
EINECS	692-949-8
Chemical Formula	C18H14F4N2O4S
Molecular Weight	430.37
inchi	InChI=1/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	(R)-Bicalutamide (R)-Bicalutamide MedChemExpress (MCE) HY-108250 113299-40-4 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions (R)-Bicalutamide (R)-Bicalutamide MedChemExpress (MCE) HY-108250 113299-40-4 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer. Bicalutamide (HY-14249) is available as a racemic mixture. The R isomer (R-bicalutamide) has an ≈30-fold higher binding affinity to the AR than the S isomer[1]. (R)-bicalutamide (0.02-20 μM) reduces na ve LNCaP cells survival in a dose-dependent manner[2]. (R)-Bicalutamide (10 mg/kg i.g. daily for 4 days) has antitumor efficacy in VCaP xenografts mice[3]. AR[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Hongli Liu, et al. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation. J Comput Aided Mol Des. 2016 Dec 30(12):1189-1200. [Content Brief] [2]. Sara Pignatta, et al. Prolonged exposure to (R)-bicalutamide generates a LNCaP subclone with alteration of mitochondrial genome. Mol Cell Endocrinol. 2014 Jan 25 382(1):314-324. [Content Brief] [3]. Anna Tesei, et al. Effect of Small Molecules Modulating Androgen Receptor (SARMs) in Human Prostate Cancer Models. PLoS One. 2013 8(5): e62657. [Content Brief]
Supplier Website	https://www.medchemexpress.com/r-bicalutamide.html
Last Update	2025-05-21 16:50:25

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