4-Hydroxyindole MedChemExpress (MCE)

Product Name	4-Hydroxyindole
Synonyms	4-INDOLOL INDOL-4-OL 1H-INDOL-4-OL 1H-INDOLE-4-OL 4-Hdroxyindole 4-Hydroxylndole 4-hydroxy-indol Synonyms 4-INDOLOL INDOL-4-OL 1H-INDOL-4-OL 1H-INDOLE-4-OL 4-Hdroxyindole 4-Hydroxylndole 4-hydroxy-indol 4-HYDROXYINDOLE 4-Hydroxyindole 4-Hydroxxyindole 4-hydroxy indole 4-HYDROXY-1H-INDOLE 1,5-dihydro-4H-indol-4-one 4-Hydroxy Indole (4-Indolol) 4-Hydroxyindole in stock Factory
CAS	2380-94-1
EINECS	219-177-2
Chemical Formula	C8H7NO
Molecular Weight	133.15
inchi	InChI=1/C8H7NO/c10-8-3-1-2-7-6(8)4-5-9-7/h1-2,4-5,9H,3H2
Package	10 mM * 1 mL;1 g;5 g;10 g;25 g;50 g;100 g
Price	Email to quote
Descriptions	4-Hydroxyindole 4-Hydroxyindole MedChemExpress (MCE) HY-34596 2380-94-1 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions 4-Hydroxyindole 4-Hydroxyindole MedChemExpress (MCE) HY-34596 2380-94-1 98.0% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. 4-Hydroxyindole is a type of hydroxyindole in which the 1H-indole at position 4 is substituted by a hydroxyl group. 4-Hydroxyindole serves as an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. 4-Hydroxyindole inhibits amyloid fibrillization and induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice. 4-Hydroxyindole holds potential for research in neurodegenerative diseases and metabolic disorders. 4-Hydroxyindole (0–200 μM, 24 h) inhibits amyloid β (Aβ1-42, 5 μM) fibrillization in a dose-dependent manner, with an IC50 of approximately 85 μM[2]. Kinetic studies shows that 4-Hydroxyindole (5–50 μM, 14 days) inhibits amyloid β aggregation during the elongation phase. Amyloid fibrillization consists of three phases: nucleation (lag phase), elongation phase, and equilibrium phase. At 5 μM, Aβ1-40 fibrillization was inhibited by approximately 60%, while at 25 μM and 50 μM, fibrillization was almost completely suppressed[2]. 4-Hydroxyindole (5–50 μM) dose-dependently blocks amyloid β-induced toxicity in PC12 cells[1]. 4-Hydroxyindole (620 mg/kg) and its oxidation product (320 mg/kg) (intracranial injection, single-dose administration) induces liver function impairment, thyroid abnormalities, and blood glucose fluctuations in mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar 38(3):386-95. [Content Brief] [2]. Cohen T, et al. Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. Biochemistry. 2006 Apr 18 45(15):4727-35. [Content Brief] [3]. Goyal R N, et al. Electrochemical oxidation of 4-hydroxyindole and effects of its oxidation products on blood parameters of albino mice[J]. Bioorganic Chemistry, 1999, 27(3): 239-252.
Supplier Website	https://www.medchemexpress.com/4-hydroxyindole.html
Last Update	2025-05-21 16:50:25

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