ST1481 MedChemExpress (MCE)

Product Name	Gimatecan
Synonyms	ST1481;LBQ707;CPT 184; ST1481; CPT 184;GIMATECAN;Gimatecan;7-T-Butoxyiminomethylcamptothecin
CAS	292618-32-7
EINECS
Chemical Formula	C25H25N3O5
Molecular Weight	447.488
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Gimatecan Gimatecan MedChemExpress (MCE) HY-B0063 292618-32-7 ST1481 99.28% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Gimatecan Gimatecan MedChemExpress (MCE) HY-B0063 292618-32-7 ST1481 99.28% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. Gimatecan (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency[1]. Gimatecan causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL)[1]. Gimatecan (2 mg/kg treatment per os, every fourth day for four times) is effective for inhibiting tumor growth[1]. Topoisomerase I \| \| \| \| \| \| \| \| \| \| [1]. Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb 7(2):152-61. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gimatecan.html
Last Update	2025-05-21 16:50:25

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