OSI-420 free base; CP-373420 MedChemExpress (MCE)

Product Name	OSI-420, Free Base (Desmethyl Erlotinib)
Synonyms	OSI-420 Erlotinib-10 OSI-420Free Base OSI-420 impurity 6-O-Desmethyl Erlotinib Erlotinib 6-O-Desmethyl Metabolite Erlotinib Hydrochloride iMpurity 9 Synonyms OSI-420 Erlotinib-10 OSI-420Free Base OSI-420 impurity 6-O-Desmethyl Erlotinib Erlotinib 6-O-Desmethyl Metabolite Erlotinib Hydrochloride iMpurity 9 Erlotinib O-Desmethyl Metabolite Isomer OSI-420, Free Base (Desmethyl Erlotinib) 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy) 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quizolin-6-yl)oxy)ethan-1-ol
CAS	183321-86-0
EINECS
Chemical Formula	C21H21N3O4
Molecular Weight	379.41
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Desmethyl Erlotinib Desmethyl Erlotinib MedChemExpress (MCE) HY-13256A 183321-86-0 OSI-420 free base Descriptions Desmethyl Erlotinib Desmethyl Erlotinib MedChemExpress (MCE) HY-13256A 183321-86-0 OSI-420 free base CP-373420 98.77% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor. Desmethyl Erlotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats[1]. \| \| \| \| \| \| \| \| \| \| [1]. Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm. 2012 Jul-Sep 80(3):633-46. [Content Brief]
Supplier Website	https://www.medchemexpress.com/desmethyl-erlotinib.html
Last Update	2025-05-21 16:50:25

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