Trimetazidine MedChemExpress (MCE)

Product Name	trimetazidine
Synonyms	AKOS B006602 trimetazidine TRIMETAZIDINE TRIMETAZIDINE HCL ART-CHEM-BB B006602 ART-CHEM-BB B014361 TIMTEC-BB SBB007020 Synonyms AKOS B006602 trimetazidine TRIMETAZIDINE TRIMETAZIDINE HCL ART-CHEM-BB B006602 ART-CHEM-BB B014361 TIMTEC-BB SBB007020 1-(2,3,4-trimethoxybenzyl)piperazine 1-(2,3,4-TRIMETHOXY-BENZYL)-PIPERAZINE 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
CAS	5011-34-7
EINECS	225-690-2
Chemical Formula	C14H22N2O3
Molecular Weight	266.34
inchi	InChI=1/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Trimetazidine Trimetazidine MedChemExpress (MCE) HY-B0968A 5011-34-7 99.82% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions Trimetazidine Trimetazidine MedChemExpress (MCE) HY-B0968A 5011-34-7 99.82% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor. Trimetazidine (1-100 μM 24 hours HUVECs) could enhance the viability of the injured HUVECs induced by oxidation in a certain dose-dependent manner[1]. Trimetazidine (5-20 mg/kg oral administration 1 hour Swiss albino male mice) in 10 and 20mg/kg doses significantly raises the seizure-threshold current in the ICES test in the mice[5]. IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2] β-oxidation[2] Autophagy[3] 3-hydroxyacyl-CoA dehydrogenase (HADHA)[4] In Vitro Trimetazidine (1-100 μM 24 hours HUVECs) could enhance the viability of the injured HUVECs induced by oxidation in a certain dose-dependent manner[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Trimetazidine Related Antibodies Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) \| \| \| \| \| \| \| \| \| \| [1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun 74(9):971-80. [Content Brief] [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17 86(5):580-8. [Content Brief] [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov 3(11):1236-47. [Content Brief] [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun 19(5):300-2. [Content Brief]
Supplier Website	https://www.medchemexpress.com/trimetazidine.html
Last Update	2025-05-21 16:50:25

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