Melphalan flufenamide hydrochloride MedChemExpress (MCE)

Product Name	Nelotanserin
Synonyms	Nelotanserin;MELFLUFEN HYDROCHLORIDE;Melflufen hydrochloride;ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate
CAS	380449-54-7
EINECS
Chemical Formula	C24H31Cl3FN3O3
Molecular Weight	534.88
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Melflufen hydrochloride Melflufen hydrochloride MedChemExpress (MCE) HY-105019A 380449-54-7 Melphalan flufenamide hydrochloride 98.73% 4°C, sealed storage, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions Melflufen hydrochloride Melflufen hydrochloride MedChemExpress (MCE) HY-105019A 380449-54-7 Melphalan flufenamide hydrochloride 98.73% 4°C, sealed storage, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells. Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1]. Melflufen hydrochloride induces apoptosis in MM.1S cells[1]. Melflufen hydrochloride also is a potent activator of exosome secretion[3]. Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg i.v. twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1]. \| \| \| \| \| \| \| \| \| \| [1]. Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013 19(11):3019-3031. [Content Brief] [2]. Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016 174(3):397-409. [Content Brief] [3]. McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30 18(1):52. [Content Brief]
Supplier Website	https://www.medchemexpress.com/melflufen-hydrochloride.html
Last Update	2025-05-21 16:50:25

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