TIE-2/VEGFR-2 kinase-IN-1 MedChemExpress (MCE)

Product Name	TIE-2/VEGFR-2 kinase-IN-1
Synonyms	Kinase IN-1;6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE;6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine
CAS	453590-24-4
EINECS
Chemical Formula	C13H11N3O2
Molecular Weight	241.25
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	TIE-2/VEGFR-2 kinase-IN-1 TIE-2/VEGFR-2 kinase-IN-1 MedChemExpress (MCE) HY-112294 453590-24-4 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions TIE-2/VEGFR-2 kinase-IN-1 TIE-2/VEGFR-2 kinase-IN-1 MedChemExpress (MCE) HY-112294 453590-24-4 99.91% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis. Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1].Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis. Tie2 \| \| \| \| \| \| \| \| \| \| [1]. Jerry Leroy Adams, et al. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors. Patent WO2003022852.
Supplier Website	https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-1.html
Last Update	2025-05-21 16:50:25

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