9-Decyn-1-ol MedChemExpress (MCE)

Product Name	9-DECYN-1-OL
Synonyms	ec-9-yn-1-ol;2-DECYN-2-OL;9-DECYN-1-OL;Dec-9-yn-1-ol;10-Hydroxy-1-decyne
CAS	17643-36-6
EINECS	217-102-8
Chemical Formula	C10H18O
Molecular Weight	154.25
inchi	InChI=1/C10H18O/c1-2-3-4-5-6-7-8-9-10-11/h1,11H,3-10H2
Package	1 g;5 g;10 g
Price	Email to quote
Descriptions	9-Decyn-1-ol 9-Decyn-1-ol MedChemExpress (MCE) HY-130985 17643-36-6 Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 9-Decyn-1-ol 9-Decyn-1-ol MedChemExpress (MCE) HY-130985 17643-36-6 Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1]. Alkyl/ether \| \| \| \| \| \| \| \| \| \| [1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16 27(1):66-73.e7. [Content Brief]
Supplier Website	https://www.medchemexpress.com/9-decyn-1-ol.html
Last Update	2025-05-21 16:50:25

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