CG347B MedChemExpress (MCE)

Product Name	2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester
Synonyms	CG347B;CTTSUGRYXUPYIO-UHFFFAOYSA-N;2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 2-[(1-phenylcyclopropyl)amino]-, ethyl ester
CAS	1598426-03-9
EINECS
Chemical Formula	C16H17N3O2
Molecular Weight	283.33
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	CG347B CG347B MedChemExpress (MCE) HY-135890 1598426-03-9 98.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions CG347B CG347B MedChemExpress (MCE) HY-135890 1598426-03-9 98.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research. HtrA1 is identified as a Cisplatin (HY-17394, CDDP) resistance-related gene in NSCLC cells, while CG347B shows no effect on normalized mRNA expression or protein level of HtrA1 in NCI-H460 (CDDP-resistant) cells[1]. CG347B (200 nM 48 h) slightly rescues the Foxp3 expression inhibition induced by IL-4 (15 ng/mL), indicating a potential inhibition happens on histone deacetylation in naive CD4+ T cells from WT B6 mice cultured under Treg-polarizing conditions (for 1-3 d)[3]. HDAC6 \| \| \| \| \| \| \| \| \| \| [1]. Wang W, et al. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Mol Cancer. 2020 Sep 2 19(1):134. [Content Brief] [2]. Christopher M. YATES. Metalloenzyme inhibitor compounds. WO2018165520A1. [3]. Cui J, et al. IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation. Cell Death Dis. 2021 May 18 12(6):501. [Content Brief]
Supplier Website	https://www.medchemexpress.com/cg347b.html
Last Update	2025-05-21 16:50:25

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