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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameOXFBD04
SynonymsOXFBD04
CAS2231747-03-6
EINECS
Chemical FormulaC17H16N2O3
Molecular Weight296.33
inchi
Package10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
PriceEmail to quote
DescriptionsOXFBD04

OXFBD04

MedChemExpress (MCE)

HY-135236

2231747-03-6

98.99%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US

Descriptions

OXFBD04

OXFBD04

MedChemExpress (MCE)

HY-135236

2231747-03-6

98.99%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US
may vary elsewhere.

OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.

OXFBD04 (0.01-100 μM
48 hours) inhibits cancer cell lines growth[1]. OXFBD04 (10 µM
for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells[1].

OXFBD04 has optimised physicochemical properties (LE=0.43
LLE=5.74
SFI=5.96), and good metabolic stability (t1/2=388 min). OXFBD04 has CLint of 3.57 µL/min/mg[1].

BRD4 166 nM (IC50)

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[1]. Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15
26(11):2937-2957. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/oxfbd04.html
Last Update2025-04-01 14:45:47
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