Pyroxamide MedChemExpress (MCE)

Product Name	N-hydroxy-N'-(pyridin-3-yl)octanediamide
Synonyms	NSC 696085 NSC696085 Pyroxamide NSC-696085 382180-17-8 NSC 696085 PyroxaMide (NSC 696085) Synonyms NSC 696085 NSC696085 Pyroxamide NSC-696085 382180-17-8 NSC 696085 PyroxaMide (NSC 696085) N-Hydroxy-N'-3-pyridinyloctanediamide N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE N1-Hydroxy-N8-3-pyridinyl-octanediamide N-hydroxy-N'-(pyridin-3-yl)octanediamide n-hydroxy-n'-(pyridin-3-yl)octanediamide N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE N1-Hydroxy-N8-(pyridin-3-yl)octanediamide 2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide
CAS	382180-17-8
EINECS
Chemical Formula	C13H19N3O3
Molecular Weight	265.31
inchi	InChI=1/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Pyroxamide Pyroxamide MedChemExpress (MCE) HY-13216 382180-17-8 99.54% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Pyroxamide Pyroxamide MedChemExpress (MCE) HY-13216 382180-17-8 99.54% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia. Pyroxamide (1.25-20.0 μM 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1]. Pyroxamide (10.0-20.0 μM 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1]. HDAC1 100 nM (ID50) \| \| \| \| \| \| \| \| \| \| [1]. Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr 7(4):962-70. [Content Brief] [2]. Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15 9(15):5749-55. [Content Brief]
Supplier Website	https://www.medchemexpress.com/pyroxamide.html
Last Update	2025-04-01 14:45:47

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