ChemBK
  • Home
  • Product Category
  • CHN
  1. Home
  2. CAS 796073-68-2
  3. Supplier List
  4. MedChemExpress (MCE)
  5. Signaling Pathways
  6. DM4-SMe

Request for quotation








Supplier Contact

Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
QQ
Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
Wechat
Product NameDM4-Sme
SynonymsDM4-SME;DM4-Sme;Maytansinoid DM4 Impurity 1;MAYTANSINOID DM4 IMPURITY 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
CAS796073-68-2
EINECS
Chemical FormulaC39H56ClN3O10S2
Molecular Weight826.46
inchi
Package1 mg
PriceEmail to quote
DescriptionsDM4-SMe

DM4-SMe

MedChemExpress (MCE)

HY-130082

796073-68-2

99.99%

Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US

Descriptions

DM4-SMe

DM4-SMe

MedChemExpress (MCE)

HY-130082

796073-68-2

99.99%

Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US
may vary elsewhere.

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM.

Maytansinoids

| | | |

| | | | | |



[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1
12(6):1762-73. [Content Brief]

[2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1
22(8). [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/dm4-sme.html
Last Update2025-05-21 16:50:25
MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25
  • Home
  • Product Category

© 2015 ChemBK.com All Rights Reserved | Build: 20150530002