RX 781094 hydrochloride MedChemExpress (MCE)

Product Name	Idazoxan Hydrochloride
Synonyms	RX 781094A IdazoxanHCl Idazoxan Hydrochloride IDAZOXAN HYDROCHLORIDE 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride Synonyms RX 781094A IdazoxanHCl Idazoxan Hydrochloride IDAZOXAN HYDROCHLORIDE 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
CAS	79944-56-2
EINECS
Chemical Formula	C11H13ClN2O2
Molecular Weight	240.69
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Idazoxan hydrochloride Idazoxan hydrochloride MedChemExpress (MCE) HY-14561A 79944-56-2 RX 781094 hydrochloride 99.32% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Idazoxan hydrochloride Idazoxan hydrochloride MedChemExpress (MCE) HY-14561A 79944-56-2 RX 781094 hydrochloride 99.32% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism. Idazoxan (0.16-5 mg/kg subcutaneous injection for 1 hour male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1]. α adrenergic receptor \| \| \| \| \| \| \| \| \| \| [1]. Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003). [Content Brief] [2]. Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21 881:272-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/idazoxan-hydrochloride.html
Last Update	2025-05-21 16:50:25

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