BMS-195270 MedChemExpress (MCE)

Product Name	3H-1,2,4-Triazol-3-one, 2-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-[2-(trifluoromethyl)phenyl]-
Synonyms	3H-1,2,4-Triazol-3-one, 2-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-[2-(trifluoromethyl)phenyl]- BMS-195270 CHEMBL13637 SCHEMBL5754043 UNII-20UM0T170J 2-(5-Chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-one
CAS	202822-23-9
EINECS
Chemical Formula	C15H9ClF3N3O2
Molecular Weight	355.7
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	BMS-195270 BMS-195270 MedChemExpress (MCE) HY-120620 202822-23-9 97.52% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions BMS-195270 BMS-195270 MedChemExpress (MCE) HY-120620 202822-23-9 97.52% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux. BMS-195270 (3 μM) produces a dramatic reduction in developed pressure at infusion volumes of 0.2-1.3 mL and inhibits spontaneous contractions in an ex vivo rat whole bladder model[1]. BMS-195270 (2.8 mM) results adult worms of C. elegans displaying an Egl-d phenotype, as well as slowed or arrested pharyngeal pumping (Eat), and uncoordinated motion (Unc)[1]. BMS-195270 inhibits the response of HEK293 cells to the muscarinic agonist Carbachol (HY-B1208) with an EC50 of 2 μM[1]. BMS-195270 inhibits calcium flux, and retains inhibitory activity even when endogenous calcium channels are inactivated[1]. \| \| \| \| \| \| \| \| \| \| [1]. Fitzgerald K, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr 2(4):e57. [Content Brief]
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Last Update	2025-05-21 16:50:25

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