ML252 MedChemExpress (MCE)

Product Name	ML 252
Synonyms	ML 252;(2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide;(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide;Benzeneacetamide, α-ethyl-N-[2-(1-pyrrolidinyl)phenyl]-, (αS)-
CAS	1392494-64-2
EINECS
Chemical Formula	C20H24N2O
Molecular Weight	308.42
inchi
Package	5 mg;10 mg
Price	Email to quote
Descriptions	ML252 ML252 MedChemExpress (MCE) HY-18063 1392494-64-2 99.9% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions ML252 ML252 MedChemExpress (MCE) HY-18063 1392494-64-2 99.9% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant . ML252 (1 μM 0-48 h) shows an intrinsic clearance and subsequent predicted hepativ clearance of 1720 mL/min/kd and 67.3 mL/min/kg, respectively, in rat hepatic microsomes[1]. ML252 (0.1-10 μM) inhibits the current of KCNQ2 at 0.3 μM, and completely inhibits the current at 1 μM in CHO-KCNQ2 cell line[1]. ML252 (30 μM 48 h) has no acute toxicity to CHO cells[1]. ML252 has the metabolic stability unsuitable for oral administration[2]. ML252 (10 mg/kg, 3 mg/mL ip single dose measured at 1 hr after) shows a highly brain penetrant with a B:P ratio of 1.9 and absolute brain levels of 672 nM in rat model[1]. KCNQ2 69 nM (IC50) KCNQ1 2.92 μM (IC50) KCNQ2/Q3 0.12 μM (IC50) KCNQ4 0.20 μM (IC50) CYP1A2 6.1 μM (IC50) CYP2C9 18.9 μM (IC50) CYP2D6 19.9 μM (IC50) CYP3A4 3.9 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Yu H, et al. Identification of a novel, small molecule inhibitor of KCNQ2 channels. 2011 Oct 28 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US) 2010–. [Content Brief] [2]. Cheung YY, et al. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. J Med Chem. 2012 Aug 9 55(15):6975-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ml252.html
Last Update	2025-05-21 16:50:25

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