LY-3484356 tosylate MedChemExpress (MCE)

Product Name	(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol 4-methylbenzenesulfonate
Synonyms	(R)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol 4-methylbenzenesulfonate
CAS	2408840-41-3
EINECS
Chemical Formula	C36H32F4N2O6S
Molecular Weight	696.71
inchi
Package	1 mg
Price	Email to quote
Descriptions	Imlunestrant tosylate Imlunestrant tosylate MedChemExpress (MCE) HY-145572A 2408840-41-3 LY-3484356 tosylate 98.54% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Imlunestrant tosylate Imlunestrant tosylate MedChemExpress (MCE) HY-145572A 2408840-41-3 LY-3484356 tosylate 98.54% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC). LY3484356 shows favorable pharmacokinetic (PK) properties, including antitumor activity in ESR1 mutants[1]. \| \| \| \| \| \| \| \| \| \| [1]. Komal L. Jhaveri, et al. A first-in-human phase 1a/b trial of LY3484356, an oral selective estrogen receptor (ER) degrader (SERD) in ER+ advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC): Results from the EMBER study. 2021 ASCO Annual Meeting I. [2]. Cristina Hernando, et al. Oral Selective Estrogen Receptor Degraders (SERDs) as a Novel Breast Cancer Therapy: Present and Future from a Clinical Perspective. Int. J. Mol. Sci. 2021, 22(15), 7812.
Supplier Website	https://www.medchemexpress.com/imlunestrant-tosylate.html
Last Update	2025-05-21 16:50:25

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