KV2 channel inhibitor-1 MedChemExpress (MCE)

Product Name	Kv2-IN-A1
Synonyms	Kv2-IN-A1;Benzenepropanamide, 3-chloro-β-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-
CAS	689297-68-5
EINECS
Chemical Formula	C20H17ClN4OS
Molecular Weight	396.89
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	KV2 channel inhibitor-1 KV2 channel inhibitor-1 MedChemExpress (MCE) HY-44153 689297-68-5 98.46% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions KV2 channel inhibitor-1 KV2 channel inhibitor-1 MedChemExpress (MCE) HY-44153 689297-68-5 98.46% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. KV2 channel inhibitor-1 is a selective KV2 channel inhibitor with IC50s of 0.2 μM and 0.41 μM for KV2.1 and KV2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over KV1.2 (IC50>10 μM). KV2 channel inhibitor-1 is >10-fold selective over NaV channels and other KV channels and displays weak activity on CaV channels. KV2 channel inhibitor-1 (compound A1 0.3, 1, 3 μM 0-3000s) inhibits the KV current in rat insulinoma INS-1 cells. KV2 channel inhibitor-1 blocks INS-1 KV current an average of 71% at 0.3 μM and 84% at 3 μM[1]. IC50: 0.2 μM (KV2.1), 0.41 μM (KV2.2), 12.1 μM (KV1.2), 9.5 μM (KV1.5), >20 μM (KV3.2), 2.9 μM (KV11.1), 6.6 μM (CaV1.2), >10 μM (CaV2.1), >10 μM (CaV2.2), 5.7 μM (CaV2.3), >10 μM (NaV1.5), 8 μM (NaV1.7)[1] In Vitro KV2 channel inhibitor-1 (compound A1 0.3, 1, 3 μM 0-3000s) inhibits the KV current in rat insulinoma INS-1 cells. KV2 channel inhibitor-1 blocks INS-1 KV current an average of 71% at 0.3 μM and 84% at 3 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KV2 channel inhibitor-1 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. James Herrington, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec 80(6):959-64. [Content Brief]
Supplier Website	https://www.medchemexpress.com/kv2-channel-inhibitor-1.html
Last Update	2025-05-21 16:50:25

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