VUF6002 MedChemExpress (MCE)

Product Name	(6-CHLORO-1H-BENZOIMIDAZOL-2-YL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE
Synonyms	JNJ 10191584 PIPERAZINE, 1-[(5-CHLORO-1H-BENZIMIDAZOL-2-YL)CARBONYL]-4-METHYL- Methanone, (6-chloro-1H-benzimidazol-2-yl)(4-methyl-1-piperazinyl)- (6-CHLORO-1H-BENZOIMIDAZOL-2-YL)-(4-METHYL-PIPERAZIN-1-YL)-METHANONE
CAS	73903-17-0
EINECS
Chemical Formula	C13H15ClN4O
Molecular Weight	278.74
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	JNJ10191584 JNJ10191584 MedChemExpress (MCE) HY-123532 73903-17-0 VUF6002 99.95% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions JNJ10191584 JNJ10191584 MedChemExpress (MCE) HY-123532 73903-17-0 VUF6002 99.95% 4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively. JNJ10191584 shows binding affinity of 26 nM and 14.1 μM to H4 and H3 receptor, respectively[1]. JNJ10191584 (3 h) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively[1]. JNJ10191584 (10 μg/μL intra locus coeruleus (LC) administration once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice[1]. JNJ10191584 (10 μg/μL intra LC administration once) prevents the anti-allodynic effect of VUF 8430 in SNI mice[1]. JNJ10191584 (6 μg/mouse intrathecal administration pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice[1]. Human H4 Receptor 26 nM (Ki) human H3 receptor 14.1 μM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29 48(26):8289-98. [Content Brief] [2]. Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5 868:172859. [Content Brief]
Supplier Website	https://www.medchemexpress.com/jnj10191584.html
Last Update	2025-05-21 16:50:25

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