LS 519 free base; Pirenzepin; Gastrozepin MedChemExpress (MCE)

Product Name	Gastrozepin
Synonyms	LS-519-C12 Pirenzepine Gastrozepin PIRENZEPINE DIHYDROCHLORIDE MONOHYDRATE 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6h-pyrido(2,3-b)(1,4)benzod 11-((4-methyl-1-piperazinyl)acetyl)-5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzod Synonyms LS-519-C12 Pirenzepine Gastrozepin PIRENZEPINE DIHYDROCHLORIDE MONOHYDRATE 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6h-pyrido(2,3-b)(1,4)benzod 11-((4-methyl-1-piperazinyl)acetyl)-5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzod 6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((4-methyl-1-piperazi 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 1-methyl-4-[2-oxo-2-(6-oxo-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)ethyl]piperazinediium
CAS	28797-61-7
EINECS	249-228-4
Chemical Formula	C19H21N5O2
Molecular Weight	351.4
inchi	InChI=1/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)/p+2
Package	10 mM * 1 mL;50 mg;100 mg;500 mg
Price	Email to quote
Descriptions	Pirenzepine Pirenzepine MedChemExpress (MCE) HY-17037A 28797-61-7 LS 519 free base Descriptions Pirenzepine Pirenzepine MedChemExpress (MCE) HY-17037A 28797-61-7 LS 519 free base Pirenzepin Gastrozepin 99.02% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells. Pirenzepine (100-140 μg/mL 24 h) inhibits PC-3 cell proliferation activity[2]. Pirenzepine (110 μg/mL 24 h) inhibits prostate and lung cancer cell migration[2]. Pirenzepine (100-130 μg/mL 0-24 h) inhibits the expression of GLI1 in PC-3 cells[2]. Pirenzepine (intraperitoneal injection 0.3 mg/kg once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock[3]. \| \| \| \| \| \| \| \| \| \| [1]. Carmine AA, et al. Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. Drugs. 1985 Aug 30(2):85-126. [Content Brief] [2]. Yin QQ, et al. Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling. Asian J Androl. 2018 Nov-Dec 20(6):608-614. [Content Brief] [3]. Yabuki Y, et al. The T-type calcium channel enhancer SAK3 inhibits neuronal death following transient brain ischemia via nicotinic acetylcholine receptor stimulation. Neurochem Int. 2017 Sep 108:272-281. [Content Brief]
Supplier Website	https://www.medchemexpress.com/pirenzepine.html
Last Update	2025-05-21 16:50:25

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