JMS-17-2 MedChemExpress (MCE)

Product Name	Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
Synonyms	JMS-17-2;5-(3-(4-(4-chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one;Pyrrolo[1,2-a]quinoxalin-4(5H)-one,5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-
CAS	1380392-05-1
EINECS	604-604-1
Chemical Formula	C25H26ClN3O
Molecular Weight	419.95
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	JMS-17-2 JMS-17-2 MedChemExpress (MCE) HY-123918 1380392-05-1 99.59% 4°C, protect from light In solvent : -80°C, 6 months Descriptions JMS-17-2 JMS-17-2 MedChemExpress (MCE) HY-123918 1380392-05-1 99.59% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells. JMS-17-2 (10 mg/kg aministered i.p. twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1]. IC50: 0.32 nM (CX3CR1)[1] In Vivo JMS-17-2 (10 mg/kg aministered i.p. twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: SCID mice (~25g) with MDA-231 xenograft[1] \| \| \| \| \| \| \| \| \| \| [1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun 14(6):518-27. [Content Brief]
Supplier Website	https://www.medchemexpress.com/jms-17-2.html
Last Update	2025-05-21 16:50:25

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