NecroX-5 MedChemExpress (MCE)

Product Name	Necrox-5 (methanesulfonate)
Synonyms	NecroX-5;NecroX-5 mesylate;ZWWWDIWEZYRVMB-UHFFFAOYSA-N;Necrox-5 (methanesulfonate)
CAS	1383718-29-3
EINECS
Chemical Formula	C27H39N3O9S3
Molecular Weight	645.808
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	NecroX-5 NecroX-5 MedChemExpress (MCE) HY-104015 1383718-29-3 98.16% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions NecroX-5 NecroX-5 MedChemExpress (MCE) HY-104015 1383718-29-3 98.16% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels[1]. NecroX-5 (10 μM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells[2]. NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice[1]. Calcium channel[1] In Vitro NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels[1]. NecroX-5 (10 μM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NecroX-5 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Park JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017 Jan 50(1):185-192. [Content Brief] [2]. Thu VT, et al. NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. Korean J Physiol Pharmacol. 2016 May 20(3):305-14. [Content Brief]
Supplier Website	https://www.medchemexpress.com/NecroX-5.html
Last Update	2025-05-21 16:50:25

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