Leu-AMS MedChemExpress (MCE)

Product Name	Leu-AMS
Synonyms	Leu-AMS;288591-93-5;Adenosine, 5'-[[(2S)-2-amino-4-methyl-1-oxopentyl]sulfamate]
CAS	288591-93-5
EINECS
Chemical Formula	C16H25N7O7S
Molecular Weight	459.48
inchi
Package	10 mM * 1 mL;1 mg;5 mg
Price	Email to quote
Descriptions	Leu-AMS Leu-AMS MedChemExpress (MCE) HY-108900 288591-93-5 98.08% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Leu-AMS Leu-AMS MedChemExpress (MCE) HY-108900 288591-93-5 98.08% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria. Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1]. IC50: 22.34 nM (LRS)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Yoon S, et al. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-TargetedMammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. J Med Chem. 2016 Nov 23 59(22):10322-10328. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Leu-AMS.html
Last Update	2025-05-21 16:50:25

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