GDP366 MedChemExpress (MCE)

Product Name	GDP366
Synonyms	GDP366;GDP-366;GDP 366;501698-03-9;Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
CAS	501698-03-9
EINECS
Chemical Formula	C20H17N5OS
Molecular Weight	375.45
inchi
Package	10 mM * 1 mL;10 mM * 1 mL;1 mg;1 mg;5 mg;5 mg
Price	Email to quote
Descriptions	GDP366 GDP366 MedChemExpress (MCE) HY-U00177 501698-03-9 99.67% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions GDP366 GDP366 MedChemExpress (MCE) HY-U00177 501698-03-9 99.67% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity[1]. Survivin[1] Op18[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Shi X, et al. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biol Ther. 2010 Apr 15 9(8):640-50. [Content Brief]
Supplier Website	https://www.medchemexpress.com/GDP366.html
Last Update	2025-05-21 16:50:25

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