ACT-334441 MedChemExpress (MCE)

Product Name	Abediterol
Synonyms	CS-2487 CENERIMOD Abediterol ACT-334441 CENERIMOD ACT334441 ACT 334441 Synonyms CS-2487 CENERIMOD Abediterol ACT-334441 CENERIMOD ACT334441 ACT 334441 (S)-3-(4-(5-(2-CYCLOPENTYL-6-METHOXYPYRIDIN-4-YL)-1,2,4-OXADIAZOL-3-YL)-2-ETHYL-6-METHYLPHENOXY)PROPANE-1,2-DIOL 1,2-Propanediol, 3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-, (2S)-
CAS	1262414-04-9
EINECS
Chemical Formula	C25H31N3O5
Molecular Weight	453.53
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Cenerimod Cenerimod MedChemExpress (MCE) HY-17606 1262414-04-9 ACT-334441 99.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Cenerimod Cenerimod MedChemExpress (MCE) HY-17606 1262414-04-9 ACT-334441 99.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous. Cenerimod is a highly potent S1P1 receptor agonists in (35S)-GTPγS assays using HUVEC cell membrane preparations, with an EC50 of 2 nM[1]. Cenerimod activates G protein and increases Ca2+ signaling in CHO cells, with EC50s of 1 nM and 124 nM, respectively[1]. Cenerimod (5 μM 24 h) inhibits collagen production in fibroblasts[2]. Cenerimod (0.1-10 mg/kg a single p.o.) reversibly reduces the number of circulating lymphocytes in a dose-dependent manner in rats[1]. Cenerimod (6 mg/kg/day for 30 days p.o.) attenuates disease in a mouse experimental autoimmune encephalitis (EAE) model[1]. Cenerimod (10 mg/kg/day for 42 days p.o.) attenuates skin and lung fibrosis in Scl-cGVHD mice[2]. S1PR1 1 nM (EC50) S1PR5 36 nM (EC50) S1PR5 228 nM (EC50) S1PR4 2134 nM (EC50) \| \| \| \| \| \| \| \| \| \| [1]. Piali L, et, al. Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties. Pharmacol Res Perspect. 2017 Dec 5(6):e00370. [Content Brief] [2]. Kano M, et, al. Attenuation of murine sclerodermatous models by the selective S1P 1 receptor modulator cenerimod. Sci Rep. 2019 Jan 24 9(1):658. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Cenerimod.html
Last Update	2025-05-21 16:50:25

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