BAY 80-6946 MedChemExpress (MCE)

Product Name	BAY 80-6946 (Copanlisib)
Synonyms	Copanlisib BAY 80-6946 BAY 80-6946 (Copanlisib) 7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine 2-Amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamide Synonyms Copanlisib BAY 80-6946 BAY 80-6946 (Copanlisib) 7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine 2-Amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamide 5-Pyrimidinecarboxamide, 2-amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-
CAS	1032568-63-0
EINECS
Chemical Formula	C23H28N8O4
Molecular Weight	480.52
inchi
Package	2 mg;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Copanlisib Copanlisib MedChemExpress (MCE) HY-15346 1032568-63-0 BAY 80-6946 99.50% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Copanlisib Copanlisib MedChemExpress (MCE) HY-15346 1032568-63-0 BAY 80-6946 99.50% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity. Copanlisib (BAY 80-6946 20-200 nM 24 hours BT20 breast cancer cells) treatmemnt induces apoptosis in a subset of tumor cell lines that are resistant to Lapatinib and Trastuzumab[1]. Copanlisib (BAY 80-6946 0.5-500 nM 2 hours ELT3 cells) shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells[1]. Copanlisib potently inhibits cell proliferation in a panel of human tumor cell lines. Copanlisib has mean IC50 values of 19 nM against cell lines with PIK3CA-activating mutations and 17 nM against HER2-positive cell lines, whereas the activity in PIK3CA wild-type and HER2-negative cells is about 40-fold less potent[1]. Copanlisib (BAY 80-6946 0.5-6 mg/kg intravenous injection every second day, every third day for 60 days athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model[1]. PI3Kα 0.5 nM (IC50) PI3Kδ 0.7 nM (IC50) PI3Kβ 3.7 nM (IC50) PI3Kγ 6.4 nM (IC50) mTOR 45 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov 12(11):2319-30. [Content Brief]
Supplier Website	https://www.medchemexpress.com/BAY-80-6946.html
Last Update	2025-05-21 16:50:25

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