BML-284 MedChemExpress (MCE)

Product Name	BML-284
Synonyms	AMBMP BML-284 Wnt Agonist Wnt agonist 1 Wnt agonist 1 (BML-284) CID 11210285 hydrochloride N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride Synonyms AMBMP BML-284 Wnt Agonist Wnt agonist 1 Wnt agonist 1 (BML-284) CID 11210285 hydrochloride N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine hydrochloride
CAS	853220-52-7
EINECS
Chemical Formula	C19H18N4O3
Molecular Weight	350.37
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	BML-284 BML-284 MedChemExpress (MCE) HY-19987 853220-52-7 99.99% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions BML-284 BML-284 MedChemExpress (MCE) HY-19987 853220-52-7 99.99% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM. BML-284 (10 μM 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen (HY-B0115)[1].BML-284 (10 μM 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group[1]. BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos[1]. EC50: 700 nM (TCF-dependent transcriptional activity)[1] In Vitro BML-284 (10 μM 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen (HY-B0115)[1].BML-284 (10 μM 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BML-284 Related Antibodies Western Blot Analysis[2] Cell Line: Human gastric cancer cell lines MNK45 and AGS[1] \| \| \| \| \| \| \| \| \| \| [1]. Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18 44(13):1987-90. [Content Brief] [2]. Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb 19(2):817-824. [Content Brief] [3]. Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep 255:126889. [Content Brief]
Supplier Website	https://www.medchemexpress.com/BML-284.html
Last Update	2025-04-01 14:45:47

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