JNJ-38431055 MedChemExpress (MCE)

Product Name	APD597
Synonyms	APD597 CS-1557 APD 597 APD-597 JNJ-38431055 JNJ38431055 JNJ 38431055 Synonyms APD597 CS-1557 APD 597 APD-597 JNJ-38431055 JNJ38431055 JNJ 38431055 APD597 (JNJ-38431055) propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate 4-[[6-[(6-Methylsulfonyl-2-methylpyridin-3-yl)amino]-5-methoxypyrimidin-4-yl]oxy]piperidine-1-carboxylic acid isopropyl ester 1-Piperidinecarboxylic acid, 4-[[5-methoxy-6-[[2-methyl-6-(methylsulfonyl)-3-pyridinyl]amino]-4-pyrimidinyl]oxy]-, 1-methylethyl ester
CAS	897732-93-3
EINECS
Chemical Formula	C21H29N5O6S
Molecular Weight	479.55
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	APD597 APD597 MedChemExpress (MCE) HY-15566 897732-93-3 JNJ-38431055 99.97% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions APD597 APD597 MedChemExpress (MCE) HY-15566 897732-93-3 JNJ-38431055 99.97% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. \| \| \| \| \| \| \| \| \| \| [1]. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1 24(17):4332-4335. [Content Brief] [2]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28 7(1):4351. [Content Brief] [3]. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15 22(4):1750-1755. [Content Brief]
Supplier Website	https://www.medchemexpress.com/APD597.html
Last Update	2025-05-21 16:50:25

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