Thonzonium MedChemExpress (MCE)

Product Name	HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE
Synonyms	NC-1264 NSC-5648 tonzonium bromide THONZONIUM BROMIDE Thonzonium bromide cetyl-dimethyl-[2-[p-anisyl(2-pyrimidyl)amino]ethyl]ammonium bromide HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE Synonyms NC-1264 NSC-5648 tonzonium bromide THONZONIUM BROMIDE Thonzonium bromide cetyl-dimethyl-[2-[p-anisyl(2-pyrimidyl)amino]ethyl]ammonium bromide HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE N-hexadecyl-N-(2-(N-4-methoxybenzylpyrimidin-2-ylamino)ethyl)dimethylammonium bromide hexadecyl-[2-[(4-methoxyphenyl)methyl-pyrimidin-2-yl-amino]ethyl]-dimethyl-azanium bromide
CAS	553-08-2
EINECS	209-032-1
Chemical Formula	C32H55BrN4O
Molecular Weight	591.71
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Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Thonzonium bromide Thonzonium bromide MedChemExpress (MCE) HY-B1246 553-08-2 99.68% 4°C, stored under nitrogen, away from moisture In solvent : -80°C, 6 months Descriptions Thonzonium bromide Thonzonium bromide MedChemExpress (MCE) HY-B1246 553-08-2 99.68% 4°C, stored under nitrogen, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen, away from moisture) Room temperature in continental US may vary elsewhere. Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM). Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis[1]. \| \| \| \| \| \| \| \| \| \| [1]. Zhu X, et al. Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Biochem Pharmacol. 2016 104:118-130. [Content Brief] [2]. Chan CY, et al. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). J Biol Chem. 2012 287(13):10236-10250. [Content Brief] [3]. Sims KR, et al. Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery. Nanoscale. 2018 11(1):219-236. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Thonzonium-bromide.html
Last Update	2025-05-21 16:50:25

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