SCE-963 hydrochloride MedChemExpress (MCE)

Product Name	cefotiam hydrochloride
Synonyms	Spizef Halospor Pansporin Pansporine Abbott 48999 cefotiam hydrochloride Cefotiam Dihydrichloride Synonyms Spizef Halospor Pansporin Pansporine Abbott 48999 cefotiam hydrochloride Cefotiam Dihydrichloride Cefotiam.2HCl(Cefotiam hydrochloride) (6R-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)- (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
CAS	66309-69-1
EINECS	266-312-6
Chemical Formula	C18H23N9O4S3.HCl
Molecular Weight	562.08
inchi	InChI=1/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10 /h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31) 21H/t12-,15- inchi InChI=1/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10 /h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31) 21H/t12-,15- /m0../s1
Package	5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Cefotiam hydrochloride Cefotiam hydrochloride MedChemExpress (MCE) HY-B0734A 66309-69-1 SCE-963 hydrochloride 98.0% 4°C, sealed storage, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions Cefotiam hydrochloride Cefotiam hydrochloride MedChemExpress (MCE) HY-B0734A 66309-69-1 SCE-963 hydrochloride 98.0% 4°C, sealed storage, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria. Cefotiam (SCE-963 0-6.25 μg/mL 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1]. Cefotiam (SCE-963 0-6.25 μg/mL 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2]. Cefotiam (SCE-963 12.5-800 mg/kg i.h. twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys[1]. β-lactam \| \| \| \| \| \| \| \| \| \| [1]. Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug 18(2):257-63. [Content Brief] [2]. Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov 10(5):391-5. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Cefotiam-hydrochloride.html
Last Update	2025-05-21 16:50:25

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