8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol MedChemExpress (MCE)

Product Name	8-Hydroxy-5-nitroquinoline
Synonyms	NIROXOLINE NOTROXOLINE NITROXOLINE Nitroxoline 5-NITRO-8-QUINOLINE 5-Nitro-8-quinolinol 8-nitroquinolin-5-ol Synonyms NIROXOLINE NOTROXOLINE NITROXOLINE Nitroxoline 5-NITRO-8-QUINOLINE 5-Nitro-8-quinolinol 8-nitroquinolin-5-ol 5-NITRO-8-QUINOLINOL 5-Nitro-8-oxychinoline 5-Nitro-8-oxyquinoline 5-Nitro-8-hydroxyquinoline 8-HYDROXY-5-NITROQUINOLINE 5-NITRO-8-HYDROXYQUINOLINE 8-Hydroxy-5-nitroquinoline
CAS	4008-48-4
EINECS	223-662-4
Chemical Formula	C9H6N2O3
Molecular Weight	190.16
inchi	InChI=1/C9H6N2O3/c12-8-4-3-7(11(13)14)9-6(8)2-1-5-10-9/h1-5,12H
Package	10 mM * 1 mL;500 mg;1 g
Price	Email to quote
Descriptions	Nitroxoline Nitroxoline MedChemExpress (MCE) HY-B1159 4008-48-4 8-Hydroxy-5-nitroquinoline Descriptions Nitroxoline Nitroxoline MedChemExpress (MCE) HY-B1159 4008-48-4 8-Hydroxy-5-nitroquinoline 5-Nitro-8-quinolinol 99.90% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research. Biofilm mass synthesis is reduced by up to 80% at sub-MIC Nitroxoline (0.25-16 μg/mL) concentrations in Pseudomonas aeruginosa, and structures formed are reticulate rather than compact. In preformed biofilms, viable cell counts are reduced by 4 logs at therapeutic concentrations[1]. Nitroxoline (2.5-20 μM 24 hours) effectively inhibits cell survival of small-cell lung cancer (SCLC) cells, and induces SCLC cell apoptosis by suppressing antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulating proapoptotic protein Bim. Nitroxoline is found to downregulate MDM2 expression by inducing its proteasomal degradation, and thus upregulates p53 expression, which is a substrate protein of MDM2[2]. Nitroxoline (15-60mg/kg orally gavage) results in significant inhibition of tumor growth in the C3H/He mice bladder cancer subcutaneous model[3]. \| \| \| \| \| \| \| \| \| \| [1]. A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov 56(11):6021-5. [Content Brief] [2]. Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr 35(4):202-208. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Nitroxoline.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact