Metergoline MedChemExpress (MCE)

Product Name	METERGOLINE
Synonyms	Lyserdol liserdol METERGOLINE n-cbz-[(8β)-1,6-dimethylergolin-8-yl]methylamine N-[(1,6-Dimethylergolin-8β-yl)methyl]carbamic acid benzyl ester [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester Synonyms Lyserdol liserdol METERGOLINE n-cbz-[(8β)-1,6-dimethylergolin-8-yl]methylamine N-[(1,6-Dimethylergolin-8β-yl)methyl]carbamic acid benzyl ester [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamicacidphenylmethylester [((8beta)-1,6-Dimethylergoline-8-yl)methyl]carbamic acid phenylmethyl ester D-[(4,6,6a,7,8,9,10,10a-Octahydro-4,7-dimethyl-10aalpha-indolo[4,3-fg]quinolin-9beta-yl)methyl]carbamic acid benzyl ester N-Cbz-[(8β)-1,6-Dimethylergolin-8-yl]methylamine, [(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
CAS	17692-51-2
EINECS	241-686-3
Chemical Formula	C25H29N3O2
Molecular Weight	403.52
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Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Metergoline Metergoline MedChemExpress (MCE) HY-B1033 17692-51-2 99.89% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Metergoline Metergoline MedChemExpress (MCE) HY-B1033 17692-51-2 99.89% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation. Metergoline (3 μM) causes a 6.8±1.2 mV depolarizing shift of the steady-state activation curve of the Na+currents, and does not alter the inactivation curve[3]. Metergoline (5 mg/kg i.p.) completely blocks the response to intrathecal 5-HT (2 μg)[4]. 5-HT2A Receptor 8.64 (pKi) 5-HT2B Receptor 8.75 (pKi) 5-HT2C Receptor 8.75 (pKi) Human 5-HT7 Receptor 16 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Antony R Knight, et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug 370(2):114-23. [Content Brief] [2]. Jessica A. Knight, et al. Pharmacological Analysis of the Novel, Rapid, and Potent Inactivation of the Human 5-Hydroxytryptamine7 Receptor by Risperidone, 9-OH-Risperidone, and Other Inactivating Antagonists. Mol Pharmacol. 2009 Feb 75(2): 374-380. [Content Brief] [3]. Jun-ho Lee, et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na+ channels expressed in Xenopus oocytes. Acta Pharmacol Sin. 2014 Jul 35(7): 862-868. [Content Brief] [4]. P K Eide, et al. The behavioural response to intrathecal serotonin is changed by acute but not by repeated treatment with zimelidine or metergoline. Pharmacol Toxicol. 1991 Nov 69(5):361-4. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Metergoline.html
Last Update	2025-05-21 16:50:25

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