CL-67772 MedChemExpress (MCE)

Product Name	Amoxapine
Synonyms	amoxan Asendis Defanyl Asendin Ascendin CL 67772 Amoxepine Synonyms amoxan Asendis Defanyl Asendin Ascendin CL 67772 Amoxepine Amoxapine CL-67.772 237-867-1 2-chloro-11-piperazin-1-yldibenzo[b,f][1,4]oxazepine 2-chloro-11-pipérazin-1-yldibenzo[b,f][1,4]oxazépine 2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine 2-Chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(1-piperazinyl)- dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-
CAS	14028-44-5
EINECS	237-867-1
Chemical Formula	C17H16ClN3O
Molecular Weight	313.78
inchi	InChI=1/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
Package	10 mM * 1 mL;250 mg;500 mg
Price	Email to quote
Descriptions	Amoxapine Amoxapine MedChemExpress (MCE) HY-B0991 14028-44-5 CL-67772 99.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Amoxapine Amoxapine MedChemExpress (MCE) HY-B0991 14028-44-5 CL-67772 99.93% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death. Amoxapine (10 μM 3-48 h) reduces the cytotoxicity induced by mycobacterium bovis (BCG) and inhibits the survival of BCG in macrophages. The minimum inhibitory concentration (MIC90) for BCG is 53 μM[1]. Amoxapine (10 μM 24 h) induces autophagy in mycobacteria-infected macrophages in a mTOR-dependent manner[1]. Amoxapine (3-5 mg/kg Oral administration 2 weeks) enhances host defense against M. tuberculosis (Mtb) in mouse models[1]. Amoxapine (10 mg/kg Intraperitoneal injection 28 days) can affect the electrophysiology of rat atrial[2]. 5-HT Receptor and Serotonin Transporter[3] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Wang J, et al. FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy. Microbiol Spectr. 2022 Oct 26 10(5):e0250922. [Content Brief] [2]. Delgado C, Manzanares J, Tamargo J, Valenzuela C. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Br J Pharmacol. 1986 Feb 87(2):317-25. [Content Brief] [3]. Maudhuit C, et al. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug 33(8):1017-25. [Content Brief]
Supplier Website	https://www.medchemexpress.com/Amoxapine.html
Last Update	2025-05-21 16:50:25

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